Monday, June 24, 2013

Promising new device detects disease with drop of blood

June 24, 2013 ? An NJIT research professor known for his cutting-edge work with carbon nanotubes is overseeing the manufacture of a prototype lab-on-a-chip that would someday enable a physician to detect disease or virus from just one drop of liquid, including blood. A new study describes how NJIT research professors Reginald Farrow and Alokik Kanwal, his former postdoctoral fellow, and their team have created a carbon nanotube-based device to noninvasively and quickly detect mobile single cells with the potential to maintain a high degree of spatial resolution.

"Using sensors, we created a device that will allow medical personnel to put a tiny drop of liquid on the active area of the device and measure the cells' electrical properties," said Farrow, the recipient of NJIT's highest research honor, the NJIT Board of Overseers Excellence in Research Prize and Medal. "Although we are not the only people by any means doing this kind of work, what we think is unique is how we measure the electrical properties or patterns of cells and how those properties differ between cell types."

In the article, the NJIT researchers evaluated three different types of cells using three different electrical probes. "It was an exploratory study and we don't want to say that we have a signature," Farrow added. "What we do say here is that these cells differ based on electrical properties. Establishing a signature, however, will take time, although we know that the distribution of electrical charges in a healthy cell changes markedly when it becomes sick."

This research was originally funded by the military as a means to identify biological warfare agents. However, Farrow believes that usage can go much further and potentially detect viruses, bacteria, even cancer. The research may also someday even assess the health of good cells, such as brain neurons. Since 2010, three U.S. patents, "Method of forming nanotube vertical field effect transistor," #7,736,979 (2010); "Nanotube device and method of fabrication" #7,964,143 (2011); "Nanotube device and method of fabrication" #8,257,566 (2012) were awarded for this device. In addition, more patents have been filed.

The device (shown in photo) utilizes standard complementary metal oxide semiconductor (CMOS) technologies for fabrication, allowing it to be easily scalable (down to a few nanometers). Nanotubes are deposited using electrophoresis after fabrication in order to maintain CMOS compatibility.

The devices are spaced by six microns which is the same size or smaller than a single cell. To demonstrate its capability to detect cells, the researchers performed impedance spectroscopy on mobile human embryonic kidney (HEK) cells, neurons from mice, and yeast cells. Measurements were performed with and without cells and with and without nanotubes. Nanotubes were found to be crucial to successfully detect the presence of cells.

Carbon nanotubes are very strong, electrically conductive structures a single nanometer in diameter. That's one-billionth of a meter, or approximately ten hydrogen atoms in a row. Farrow's breakthrough is a controlled method for firmly bonding one of these submicroscopic, crystalline electrical wires to a specific location on a substrate. His method also introduces the option of simultaneously bonding an array of millions of nanotubes and efficiently manufacturing many devices at the same time.

Being able to position single carbon nanotubes that have specific properties opens the door to further significant advances. Other possibilities include an artificial pancreas, three-dimensional electronic circuits and nanoscale fuel cells with unparalleled energy density.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/m9BV1FYvmTk/130624093520.htm

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Leap Motion starts expanded beta, opens dev portal to the public, shows off Airspace app store (hands-on)

Leap Motion starts expanded beta, opens dev portal to the public, shows off Airspace app store handson

Slowly but surely Leap Motion is making its way toward a commercial release. Today, the company has announced it's moving into the next phase of beta testing and that it will be opening up its developer portal to the public later in the week. While this still won't get folks a Leap device any faster, it will let them dig into Leap's tools and code base in preparation for when they finally get one. The move marks a shift from the company's previous SDK-focused beta to a consumer-focused one that'll serve to refine the UX in Windows and OSX. Within each operating system, there will be two levels of Leap control: basic, which essentially allows you to use Leap in place of a touchscreen, and advanced to allow for more 3D controls enabled by Leap's ability to detect the pitch and yaw of hands in space.

CEO Michael Buckwald gave us this good news himself, and also gave us a preview of Airspace, Leap's app store, and a few app demos for good measure. As it turns out, Airspace is a two-pronged affair -- Airspace Store is showcase for all software utilizing the Leap API and Airspace Home is a launcher that keeps all the Leap apps that you own in one convenient place. There will be 50 apps in Airspace at the start of the beta, with offerings from pro tools and utility apps to casual games, and we got to see a few examples.

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Source: http://www.engadget.com/2013/06/24/leap-motion-expanded-beta-dev-portal-airspace-apps-hands-on/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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O3b space constellation to launch

An innovative new space network goes into orbit on Monday.

O3b will put a series of satellites 8,000km above the Earth to provide communications to those parts of the world that have poor fibre optic infrastructure.

With backing from blue chip companies such as Google, O3b believes its novel system can change the broadband experience for millions of people.

The network's first four satellites will launch from French Guiana.

They will ride a Soyuz rocket from the Sinnamary spaceport, with lift-off scheduled for 15:53 local time (18:53 GMT)

It will take just over two hours for the Soyuz's Fregat upper-stage to raise the satellites to their operational altitude.

O3b will handle primarily voice and data traffic for mobile phone operators and internet service providers. It will pick up this traffic as the spacecraft pass overhead and then relay it to ground stations, or teleports, for onward connection to global networks.

Although other satellites routinely do this, O3b is taking a markedly different approach.

By flying in a Medium-Earth Orbit of 8,000km, its satellites will be a quarter of the distance from Earth than is the case with traditional geostationary (GEO) telecommunications spacecraft, which sit some 36,000km above the planet.

This should reduce substantially the delay, or latency, of the signal as the voice or data traffic is routed via space.

"The network was designed to avoid much of the difficulty that satellite connectivity provides today which is this delay," said O3b CEO Steve Collar.

"We've all been on a satellite call and you have that 600 milliseconds delay, which doesn't sound like much but it's enough to make that connection almost unusable. It's just as much of a problem on data networks. If you are on the internet and are searching for a site, it affects your behaviour if you get slow responses. You'll stop using the service. We wanted to fix those problems and the only way to fix them is to bring the satellites closer to Earth."

O3b is promising round-trip transmission time of a little more than 100 milliseconds.

The satellites will operate in the high-frequency Ka-band and have the capability to deliver 10 beams, at 1.2Gbps per beam, to each of O3b's seven operational regions.

The company expects to start services at the end of the year, once it gets eight spacecraft in orbit, but the intention is to put up perhaps as many as 20 eventually.

It has taken about six years to put the O3b project together. Important backers include not only Google but SES, one of the big players in the traditional satellite communications business.

O3b was born from founder Greg Wyler's frustration with the difficulty of connecting a modern teleco in Rwanda to the global fibre optic network, and the constraints that placed on performance.

O3b actually stands for "other three billion" - the number of people whose poor communications experience is expected to improve over the coming decade. O3b sees itself as an important agent of that change.

"There are two billion people in the world that are connected to the internet today; there are five billion who are not; and three billion who will be in the course of the next 10-15 years," said Mr Collar. "The other three billion is our target - that's who we're trying to reach, and that's where our name comes from."

The Jersey, Channel Islands-based outfit has raised more than $1bn to build its space and ground infrastructure.

O3b's largest debt facility, over $0.5bn, is provided by HSBC, ING, CA-CIB and Dexia, and is underwritten by the French export credit agency, Coface. The agency is supporting three new space constellations, all of them built by Thales Alenia Space.

The 700kg spacecraft that TAS is building for O3b are based on the 24 spacecraft it has just finished for the Globalstar satellite phone network.

One of the challenges of running the system is tracking platforms as they move across the sky.

"The constellation will be spread equally around the equator which means you have to pick the satellite up as it comes over the horizon and follow it to the other side; and as soon as it goes out of visibility there is already another satellite waiting to be picked up," explained Philippe Nabet, the TAS programme manager on the O3b project.

"There will be three antennas at the ground stations - two to track the satellites; the third is a spare."

Jonathan.Amos-INTERNET@bbc.co.uk and follow me on Twitter: @BBCAmos

Source: http://www.bbc.co.uk/news/science-environment-23028083#sa-ns_mchannel=rss&ns_source=PublicRSS20-sa

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Can Democrats Win Back the Deep South? (Atlantic Politics Channel)

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Analysis: For Obama, a world of Snowden troubles (reuters)

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Sunday, June 23, 2013

Go big or go home: NASA's 1.3 billion-pixel panorama from Mars

NASA researchers have composed an interactive, panoramic view of Mars created with more than 900 exposures taken from the Curiosity rover.

By Elizabeth Barber,?Contributor / June 20, 2013

A slice of the panorama from NASA's Mars rover Curiosity with 1.3 billion pixels in the full-resolution version. It shows Curiosity at the 'Rocknest' site where the rover scooped up samples of windblown dust and sand.

NASA/JPL-Caltech/MSSS

Enlarge

This is Mars like we?ve never seen it before.

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NASA has released an interactive, billion-pixel view from the surface of Mars, an amalgamation of some 900 exposures shot from Curiosity?s cameras.

The grand, unearthly view stretches like a timeline of Curiosity?s journey, from the site where Curiosity collected its first rock sample to Mount Sharp, to which the rover is now chugging. The result is a landscape portrait as majestic as any Ray Bradbury novel: a red-brown, rocky desert, sloping to a distant mountain bathed in dust.

"It gives a sense of place and really shows off the cameras' capabilities," said Bob Deen of the Multi-Mission Image Processing Laboratory at NASA's Jet Propulsion Laboratory, in a statement. "You can see the context and also zoom in to see very fine details."

Deen assembled the panorama using some 850 frames from Curiosity?s telephoto camera, along with about 21 frames from its wider-angle camera and some 25 black-and-white frames from the rover?s Navigation Camera. The images were shot on different days in the fall of 2012, showing variation in atmospheric quality and light.

The 1.3-billion-pixel image can be seen at NASA?s website with zoom and pan tools that let earthling explorers tour the red planet. A scaled-down version of the photograph is also available for download.

The raw, single-frames that Curiosity sends home are regularly posted on NASA?s homepage for its rover.

Curiosity has been on Mars since August and has continuously sent back to Earth information that has changed our understanding of the far-off planet. Earlier this June, Curiosity found a rock containing clay-mineral elements that could only have formed in water ? evidence that the dusty planet once had fresh water.

Source: http://rss.csmonitor.com/~r/feeds/science/~3/ITDigjB2FBQ/Go-big-or-go-home-NASA-s-1.3-billion-pixel-panorama-from-Mars

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Suicide bomb kills at least 13 worshippers in Pakistan

By Jibran Ahmad

PESHAWAR, Pakistan (Reuters) - A suicide bombing at a Pakistani religious center killed at least 13 worshippers on Friday, the third major attack to test the new government since the Taliban vowed revenge for a U.S. drone strike that killed its deputy commander.

The spate of violence has shattered a period of relative calm after the May election that returned former prime minister Nawaz Sharif to power, and underscores the challenges he will face in restoring stability in the country torn by militant violence.

More than 60 people have been killed in less than a week from attacks that included suicide bombers targeting women students, a hospital and a funeral procession.

Friday's blast tore through a Shi'ite Muslim seminary in the volatile city of Peshawar, killing at least 13 and injuring 40, police said. Dazed victims in bloodied clothes wandered through rubble and past shattered ornate tiles.

"The bomber was brought by two other persons who shot dead the security guard," police chief Shafiullah Khan said.

It was unclear who carried out the attack. Pakistan has suffered a growing wave of sectarian killings against Shi'ite Muslims, who make up a little over 10 percent of the population.

Security forces blamed the Pakistani Taliban for the suicide bombing and for the funeral attack. The group's spokesman denied any involvement but claimed another killing, the shooting of a provincial lawmaker and his son in the commercial city Karachi.

An allied radical Sunni Islamist group that targets Shi'ite Muslims admitted to the bus and hospital attacks.

Before the election, Sharif suggested he would be willing to negotiate to end four years of war with the Taliban in rugged tribal areas. But the group withdrew an offer of talks after a May 28 drone strike killed its deputy leader, Wali-ur-Rehman.

"There was no formal session of talks with the government but both sides were making a plan when the drone carried out missile strikes," Taliban spokesman Ihsanullah Ihsan told Reuters this week.

The group vowed to teach Pakistan and the United States a lesson for the killing. It believes the Pakistani government cooperates with Washington on drone attacks.

Known as the Tehreek-e-Taliban, the Pakistani Taliban have carried out devastating attacks against the Pakistani military and civilians. It is a separate entity to the Afghan Taliban, though allied with them.

The violence has divided opinion in Pakistan and many in the military are concerned that a political settlement could effectively concede territory to the militants.

Despite the drone strike setback, some level of negotiation seems likely, all the more so since the United States and Afghan Taliban this week announced plans to talk.

(Writing by Frank Jack Daniel, Editing by Michael Roddy)

Source: http://news.yahoo.com/suicide-bomb-kills-13-worshippers-pakistan-143559889.html

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New record as haze chokes Singapore

Ashleigh Nghiem in Singapore: "This is the fourth day of choking smoke"

Pollution levels reached a new record high for a third day in a row in Singapore, as smoky haze from fires in Indonesia shrouded the city state.

The Pollutant Standards Index (PSI) hit 401 at 12:00 on Friday (04:00 GMT) - the highest in the country's history.

The haze is also affecting Malaysia, with another 100 schools closed in the south of the country.

Indonesia has prepared helicopters and cloud seeding equipment to try to tackle the fires.

Singaporean Prime Minister Lee Hsieng Loong warned on Thursday that the haze could remain in place for weeks.

"We can't tell how this problem is going to develop because it depends on the burning, it depends on the weather, it depends on the wind," he said.

"It can easily last for several weeks and quite possibly it could last longer until the dry season ends in Sumatra which may be September or October."

'Life threatening'

A PSI reading above 300 is defined as "hazardous", while Singapore government guidelines say a PSI reading of above 400 over 24 hours "may be life threatening to ill and elderly persons".

"Healthy people [may also] experience adverse symptoms that affect normal activity," the government says.

Continue reading the main story

The PSI dropped down to 143 at 17:00 (09:00 GMT), although this is still classed as "unhealthy".

Before this week's episode, the previous air pollution record was from September 1997 during the 1997-1998 South East Asian Haze, when the PSI peaked at 226.

Singapore resident Nicole Wu told the BBC that she had stayed indoors for the past two days.

Continue reading the main story

?Start Quote

I can't even see what's happening outside my house due to the smog?

End Quote Nicole Wu Singapore resident

"It's terrible. In my flat the windows are all closed with the air conditioning on," she said. "My mother has to wear a mask to go shopping."

"I can't even see what's happening outside my house due to the smog. You can't see birds [or] moving objects," she added.

Philip Koh, a doctor, told AFP news agency that the number of medical consultations he had had in the past week had increased by 20%.

"My patients are telling me they are worried about how long this is going to last and how much higher this is going to go," he said.

In Indonesia's Riau province, where the fires are concentrated, the chief of the health department Zainal Arifin said there was an "increasing number of asthma, lung, eye and skin problems due to higher CO2 levels".

"I call for residents to stay at home and reduce outdoor activities," he said.

Diplomatic strain

Singapore's National Environment Agency has started providing hourly PSI updates on its website, in addition to the three-hourly updates it previously provided.

Around 300 schools in southern Malaysia have now been closed as a result of the smog. Schools in Singapore are currently closed for the holidays.

There are also reports of flight delays in both Singapore's Changi airport and Riau province in Indonesia.

The fires are caused by illegal slash-and-burn land clearance in Sumatra, to the west of Singapore.

The smog has strained diplomatic relations between Singapore and Indonesia - two countries that usually share good relations, the BBC's Karishma Vaswani in Jakarta reports.

Mr Lee said Singapore had provided satellite date to Indonesia to help it identify companies involved and said that if any Singapore firms were involved, that would be addressed.

Indonesia's National Disaster Management Agency said it would deploy two helicopters to conduct "water-bombing" operations, as well as planes with cloud seeding equipment.

More than 100 Indonesian firefighters are attempting to put out the fires in Sumatra.

Continue reading the main story

?Start Quote

We have been fighting fires 24 hours a day for two weeks?

End Quote Ahmad Saerozi Natural resources conservation agency

However, an official in Riau province said they were "overwhelmed and in a state of emergency".

"We have been fighting fires 24 hours a day for two weeks," Ahmad Saerozi, the head of the natural resources conservation agency in Riau, told AFP news agency.

He added that the fires were in peat around three or four metres below the ground, making it particularly hard to fight them.

"It is still burning under the surface so we have to stick a hose into the peat to douse the fire," he said.

"We take one to two hours to clear a hectare, and by then another fire has started elsewhere."

Indonesian President Susilo Bambang Yudhoyono said "all the country's resources" would be mobilised to extinguish the fires.

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Source: http://www.bbc.co.uk/news/world-asia-22998592#sa-ns_mchannel=rss&ns_source=PublicRSS20-sa

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Saturday, June 22, 2013

Suicide bomb, shootings kill 9 in northern Iraq

BAGHDAD (AP) ? A suicide car bomb and other militant attacks killed nine people in northern Iraq on Saturday, as election officials announced preliminary results for local elections in two provinces that showed the bloc of the country's speaker of parliament in the lead.

The attacks are the latest in a wave of violence that has killed nearly 2,000 Iraqis since the start of April.

The deadliest attack was in al-Athba village near the northern city of Mosul, when a suicide car bomber rammed his explosives-laden car into a police patrol, a police officer said. Three civilian bystanders and one policeman died while six other people were wounded, he added.

With violence spiking sharply in recent months to levels not seen since 2008, al-Qaida in Iraq and other militant groups have been gathering strength in the area of Mosul, some 360 kilometers (220 miles) northwest of Baghdad.

In the city of Tuz Khormato, 210 kilometers (130 miles) north of Baghdad, gunmen on motorcycles riddled a civilian vehicle carrying four off-duty policemen with bullets, killing three and wounding another, a police officer said.

Another group of gunmen attacked a police checkpoint in the city of Samarra, killing two policemen and wounding four, another police officer said. Samarra is 95 kilometers (60 miles) north of Baghdad.

Police also said two civilians were killed and nine wounded when a bomb ripped through a small market late Friday in Baghdad.

Four medical officials confirmed the casualty figures. All officials spoke on condition of anonymity as they were not authorized to release information.

Meanwhile, election officials said a partial count of ballots for provincial-level elections held Thursday in Sunni-dominated Anbar and Ninevah provinces showed Sunni parliament speaker Osama al-Nujaifi's United bloc leading with the largest number of votes in both provinces. That bloc is backed by Iraqi Finance Minister Rafia al-Issawi and prominent Sunni sheik Ahmed Abu Risha.

A coalition of Kurdish parties was in second place in Ninevah, which has a sizable Kurdish minority. A bloc headed by Anbar's existing governor, Qassim al-Fahdawi, was in second place in that province.

Iraqis voted in 12 of Iraq's 18 provinces two months ago. Officials had delayed elections in Anbar and Ninevah because of what they said were security concerns, though some Iraqis questioned that rationale and dismissed it as a political ploy related to the unrest in the provinces. The provinces have been the scene of months of anti-government protests.

Final election results are expected to be released in the coming days.

Also on Saturday, the United Nations said another 27 residents of a camp housing members of an Iranian exile group have been relocated to Albania. The move follows a deadly rocket attack on the facility last week.

A total of 71 residents of Camp Liberty have now relocated to the southeast European country, which has agreed to accept 210 of them. Germany has also offered to take 100 residents. The U.N. is urging other member states to accept some of the more than 3,000 living in Iraq.

The dissident group, the Mujahedeen-e-Khalq, is the militant wing of a Paris-based Iranian opposition movement that opposes Iran's clerical regime and has carried out assassinations and bombings there. It fought alongside Saddam Hussein's forces in the 1980-88 Iran-Iraq war, and several thousand of its members were given sanctuary in Iraq. It renounced violence in 2001, and was removed from the U.S. terrorism list last year.

Iraq's government wants the MEK members to leave, and the U.N. has been working to resettle them abroad.

Two residents of Camp Liberty were killed in a June 15 rocket attack on the facility. A Shiite militant group claimed responsibility, saying it wants the group out of Iraq.

______

Associated Press writers Adam Schreck and Sameer N. Yacoub contributed to this report.

Source: http://news.yahoo.com/suicide-bomb-shootings-kill-9-northern-iraq-135621415.html

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Flowers: Pistil leads pollen in life-and-death dance

June 20, 2013 ? Pollination, essential to much of life on earth, requires the explosive death of the male pollen tube in the female ovule. In new research, Brown University scientists describe the genetic and regulatory factors that compel the male's role in the process. Finding a way to tweak that performance could expand crop cross-breeding possibilities.

Millions of times on a spring day there is a dramatic biomolecular tango where the flower, rather than adorning a dancer's teeth, is the performer. In this dance, the female pistil leads, the male pollen tubes follow, and at the finish, the tubes explode and die. A new paper in Current Biology describes the genetically prescribed dance steps of the pollen tube and how their expression destines the tube for self-sacrifice, allowing flowering plants to reproduce.

High school biology leaves off with this: In normal pollination, sperm-carrying pollen grains land on the pistil's tip, or stigma, and grow tubes down its style to reach the ovaries in the ovules at the pistil's base. Once the tubes reach their destination, they burst open and release their sperm to fertilize each of the two ovaries in every ovule.

In his lab at Brown University, Mark Johnson, associate professor of biology, studies the true complexity of intercellular communications that conduct this process with exquisite precision.

Among the fundamental biology questions at play in the sex lives of flowers, for example, are how cells recognize each other, know what to do, and know when to do it. Last year, for instance, Johnson and his research group showed how, for all the hundreds of pollen tubes that grow through the pistil, each ovule receives exactly two fertile sperm.

As we drill into the details, it's a really great system for understanding how cellular identity is established and read by another cell," Johnson said. "The moves in the dance between the pollen and the pistil are a back-and-forth [of signals] as the pollen tube is growing. It's quite a dynamic system that happens over the course of a few hours."

Making the male listen

In the new paper, Johnson's group, led by third-year graduate student Alexander Leydon, sought to discover what convinces the male pollen tubes to stop growing and burst when they reach the ovule. Scientists have begun to understand the female's commands, but not the male's ability to listen.

What they knew from a prior study is that the gene expression in pollen tubes that had grown through a pistil was much different than that of pollen tubes grown in the lab. Leydon's first step, therefore, was to see which regulators of gene expression, or transcription factors, were at work in pistil-grown pollen tubes but not in the lab-grown ones. First they found one called MYB120 and through genomic analysis found two close associates: MYB101 and MYB97.

He tagged these with fluorescing proteins and found under the microscope that these transcription factors accumulated in the nuclei of the pollen tubes as they grew in the pistil.

Having placed them at the scene, Leydon then decided to see what happens when they aren't. He grew some normal arabadopsis plants, some in which a mutation disabled only one of the transcription factors, and other ones in which the genes for all three transcription factors were disabled. Then he took the pollen from each to pollinate normal flowers. The pollen tubes from all three plants reliably made it to ovules, but in 70 percent of the ovules encountered by the triple mutants, the pollen tubes didn't stop growing and then burst. Instead they kept growing, coiling, and remaining intact.

"The pollen tube gets to the right place, which you'd think is the hardest part," Johnson said. "But once it gets there it's unable to hear the message from the female to stop growing and burst."

From there the team looked for which pollen tube-expressed genes were being regulated by the MYB transcription factors. In pollen tubes that had grown through pistils, they found 11 that were grossly underexpressed in the mutated pollen tubes, compared to normal ones.

Finally, they looked at what those genes do. They encode a variety of tasks, but one in particular got Leydon's attention because it is responsible for the secretion of a protein called a thionin.

"For the thionin, I was especially excited because they have been described as being able to essentially burst open other cells," Leydon said. "That would be something that would be able to bind to a membrane and cause a pore to form."

In other words, expressing that gene could be pushing the pollen tube's self-destruct mechanism.

"This is not just a dialogue but a dialogue that ends in death," Leydon said. "It's a really well-controlled cell death situation."

Agricultural applications?

Future work, Johnson said, will include tracking down the relevant genes more fully and determining whether thionin is indeed the pollen tube buster that the genes and their MYB-related expression seem to indicate.

The work may also have implications beyond basic science, Johnson said.

Agronomists sometimes try to cross-breed species, such as barley and wheat, in hopes of creating new crops. That can be done if the different species are closely related and share the same number of chromosomes, but fertilization often fails at the pollen tube burst-and-release step.

Among crop plants, pollination means food.

"Understanding this molecular back-and-forth at all the different levels and stages will be useful to either engineer the process or introduce genetic diversity that will allow the reproductive process to be efficient even in difficult environmental conditions," Johnson said.

In addition to Leydon and Johnson, other Brown authors are Kristin Beale, Karolina Woroniecka, Elizabeth Castner, Jefferson Chen, and Casie Horgan. Ravishankar Palanivelu of the University of Arizona is a co-author. Chen, Castner, and Woroniecka were Brown undergraduatess who joined the project as Brown-Howard Hughes Medical Institute Summer Scholars.

The National Science Foundation funded the study with grant IOS-1021917. The researchers used the Brown University Genomics Core Facility in their work.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_environment/~3/963ICN1ISqU/130620132312.htm

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Longo goes yard twice as Rays roll Yankees

By HOWIE RUMBERG

AP Sports Writer

Associated Press Sports

updated 10:51 p.m. ET June 20, 2013

NEW YORK (AP) - Evan Longoria homered twice. Matt Moore pitched impressively into the seventh inning. From Desmond Jennings to Yunel Escobar, there were contributions throughout the Tampa Bay lineup.

That's how manager Joe Maddon imagined this pesky club would perform all year.

"That's the way it's supposed to look like," Maddon said after the Rays sent the New York Yankees to their seventh loss in nine game, 8-3 Thursday night.

Longoria reached 500 career RBIs with a sacrifice fly in the third inning. He connected against Andy Pettitte (5-5) leading off the sixth and again off Joba Chamberlain to open the eighth.

Escobar hit a two-run shot off Boone Logan later in the eighth as the Rays' won a second straight after losing six of seven.

"We've had some tough losses in the past week but the guys hung in there really well," Maddon said. "It's going to be the roller coaster AL East all summer."

Tampa Bay had 14 hits after amassing 15 in a 6-2 win over Boston on Wednesday night.

The 24-year-old Moore (9-3) snapped a three-start skid. The lefty opened the season 8-0 before yielding 20 runs over 12 1-3 innings in three starts this month. He blanked the Yankees until the sixth when two walks and a single loaded the bases with no outs.

A wild pitch scored one run, Robinson Cano had a sacrifice fly and Travis Hafner followed with an RBI grounder that pulled the Yankees to 4-3.

"Things were going well until the sixth inning," Moore said. "That was kind of the makey or breaky type of moment where it's either going to be a five-run inning with Robbie Cano up, bases loaded, no outs. Or you could keep the team in the game the way we were able to."

Moore then got an out in the seventh before being lifted following Lyle Overbay's ground-rule double to left field, only the fourth hit he allowed.

Jose Lobaton opened the scoring with a sacrifice fly in the second following a wild pitch by Pettitte. Ben Zobrist had an RBI single in the third in the Rays' first visit to the Bronx this year.

Jennings and Sean Rodriguez had consecutive two-out doubles in the seventh to chase Pettitte, making his first start as a 41-year-old - his birthday was Saturday.

"For me it's another frustrating night," Pettitte said. "We come back and score three runs and I go out there and give them right back. Joe (Girardi) trusts me to get out of the inning and I can't get Rodriguez out. I need to be able to shut these guys down."

Jennings put Pettitte in trouble on the first pitch of the game, hitting a double that landed on the left-field line for his first of his three hits.

The Rays started the third with three straight singles. Jennings led off with a single and went to second when the ball scooted under center fielder Brett Gardner's glove for an error. After Rodriguez singled, Zobrist, who came in 9 for 22 (.409) against Pettitte, drove in Jennings with a single.

Longoria's sacrifice fly made it 3-0 and gave the All-Star third baseman 500 RBIs in 710 games, eighth quickest to reach the mark in major league history.

"It's a pretty good amount of RBIs. It's something I'm pretty proud of," Longoria said. "Hopefully there'll be a ton more."

In 6 2-3 innings, Pettitte gave up five runs and nine hits. He has given up 14 runs in four starts since returning from the disabled list June 3.

Pitching coach "Larry (Rothschild) said for the first five innings he didn't make a lot of mistakes, but the ones he made they hit them," manager Joe Girardi said.

NOTES: Maddon said RHP Alex Colome will start Saturday. ... Tampa Bay played its 2,500th game in franchise history. The Rays, who started out as the Devil Rays in 1998, are 1,141-1,359 overall. Rothschild was Tampa Bay's first manager. Current Rays bench coach Dave Martinez singled for the team's first hit. ... Rays ace David Price (left triceps strain) is scheduled to make his first rehabilitation start Friday for Class A Charlotte. ... There was a moment of silence for actor and Yankees fan James Gandolfini, who died Wednesday. ... Yankees broadcaster and former catcher John Flaherty was in the Rays' first lineup. ... Yankees OF Vernon Wells went 0 for 3 and is 6 for 59 in June.

? 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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Valuable 'mates

??HBT Daily: O's teammates Chris Davis and Manny Machado lead the early AL MVP race. Who does Craig Calcaterra favor for the award?

Angels mount seven-run rally vs. Felix, M's

ANAHEIM, Calif. (AP) - Staring at a seven-run deficit with Seattle's Felix Hernandez on the mound Thursday night, the Los Angeles Angels could have been excused for starting to think about the weekend.

Source: http://nbcsports.msnbc.com/id/52270549/ns/sports-baseball/

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You'll Never Lose a Floating Cork Knife at the Bottom of a Lake

You'll Never Lose a Floating Cork Knife at the Bottom of a Lake

Are you planning an early summer lakeside knife fight? To ensure you have the upper hand grab one of these floating cork knives.

Read more...

    


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/pxaUlKqwYXY/youll-never-lose-a-floating-cork-knife-at-the-bottom-o-520959306

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Sunday, June 2, 2013

LG Optimus F7 for US Cellular leaks through company documents

LG Optimus F7 for US Cellular leaks out

US Cellular isn't just looking to spice up its device roster with the ATIV Odyssey. We've obtained documents that point to LG's upper mid-range Android smartphone, the Optimus F7, also reaching the carrier in the near future. Outside of the unintrusive branding on the back, it's a very straightforward port: the F7 should still carry its 4.7-inch qHD screen, LTE data, a dual-core 1.5GHz processor, an 8MP rear camera and a 1.3MP front camera. The materials we've seen make no mention of launch details, although we're not expecting either a long wait or a high price.

[Thanks, anonymous tipster]

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/PmMiQraQfEg/

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Friday, May 17, 2013

9,000-acre wildfire in NW Wisconsin contained

TOWN OF GORDON, Wis. (AP) ? Firefighters battling a 9,000-acre in northwestern Wisconsin have contained the massive blaze.

Department of Natural Resources spokesman Robert Manwell said Thursday the fire in Douglas and Bayfield counties is 100 percent contained. Manwell says fire crews will be handling small brush fires and reworking the lines that contain the wildfire.

Authorities opened all roads in the area overnight and some residents headed back to their homes. The fire, which began Tuesday, destroyed 17 homes and 30 other structures. The DNR says no one has been hurt in the largest forest fire to hit northern Wisconsin in 33 years.

Gov. Scott Walker has declared a state of emergency in Douglas and Bayfield counties, which makes the Wisconsin National Guard available for recovery efforts. The governor plans to tour the area Thursday.

Source: http://news.yahoo.com/9-000-acre-wildfire-nw-wisconsin-contained-123821625.html

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Friday, May 3, 2013

Husband kills wife with a pickaxe, police say

Investigators say a Pittsburgh man killed his wife with a pickaxe after the couple had an argument.
?
Bruce Cook, 62, was charged Thursday with criminal homicide and abuse of a corpse in the death of 57-year-old Lois Cook.

A friend called police Wednesday because Lois Cook missed work.
?
Police said they arrived at the Cooks' home Wednesday night and found dried blood on the floor of the kitchen heading toward the basement steps. Investigators said they found Lois Cook's body under a tarp in the basement.

More news from NBC10.com
?
Police said Bruce Cook hit his wife with some type of blunt object before striking her in the head with a pickaxe.
?
A neighbor described the victim as a caring woman and referred to her husband as "a ticking time bomb."

NBC10.com

Source: http://feeds.nbcnews.com/c/35002/f/653381/s/2b75c899/l/0Lusnews0Bnbcnews0N0C0Inews0C20A130C0A50C0A30C180A310A660Ehusband0Ekills0Ewife0Ewith0Ea0Epickaxe0Epolice0Esay0Dlite/story01.htm

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Al Pacino Has Manglehorn

al pacino wallpaper hd normal 480x360 Al Pacino Set To Star In David Gordon Greens Manglehorn

David Gordon Green?s productivity amazes me. Not only is he promoting Prince Avalanche while wrapping up production on Joe (starring Nicolas Cage), but he?s also begun planning his newest film Manglehorn, and he wants Academy Award-winning actor and industry legend Al Pacino as the lead. The film would tell the story of an ex-con living in anonymity while nursing his sick cat and slowly falling into a dull routine, but his tranquility is eventually threatened when he?s unmasked as a man with a dark past.

Al Pacino?s career is at an all-time low. His latest movies make little effort to showcase his wonderful acting skills ? Stand Up Guys barely made a passing grade, The Son of No One was laughable, and nobody is willing to accept the fact that Jack and Jill even exists (except Adam Sandler, of course). Nevertheless, I still enjoy Pacino quite a bit. Maybe I?m just hanging on to the idea of a younger Pacino, who delighted audiences and critics alike with flawless performances in Serpico and Dog Day Afternoon. Perhaps Manglehorn can give the actor back the confidence to take on more serious roles, and hopefully it will get him the accolades he truly deserves.

As far as?David Gordon Green goes, well, he is an exciting filmmaker, no doubt about that. Has anyone seen his debut film George Washington? OK, probably not. Still, it?s a solid movie. How about All the Real Girls and Pineapple Express? The former was an instant indie hit, while the latter went on to become an iconic stoner film. Sounds like a fairly decent career, right? Wrong. Critical reception of the director?s later films has been intermittent, to say the least. Is intermittent the right word? I mean terrible. Despite early success with thoughtful indie dramas, somewhere down the road the guy decided to make Your Highness and The Sitter ? two tragedies in less than a year. Will he get back on track with Joe and?Manglehorn?

Manglehorn was co-written by Paul Logan and is being financed by Worldview Entertainment.

Source: http://www.rottentomatoes.com/m/1927381/news/1927381/

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Kraft Foods profit beats Street, shares rise

May 1 (Reuters) - Post position for Saturday's 139th Kentucky Derby at Churchill Downs after Wednesday's draw (listed as barrier, HORSE, jockey, trainer) 1. BLACK ONYX, Joe Bravo, Kelly Breen 2. OXBOW, Gary Stevens, D. Wayne Lukas 3. REVOLUTIONARY, Calvin Borel, Todd Pletcher 4. GOLDEN SOUL, Robby Albarado, Dallas Stewart 5. NORMANDY INVASION, Javier Castellano, Chad Brown 6. MYLUTE, Rosie Napravnik, Tom Amoss 7. GIANT FINISH, Jose Espinoza, Tony Dutrow 8. GOLDENCENTS, Kevin Krigger, Doug O'Neill 9. OVERANALYZE, Rafael Bejarano, Todd Pletcher 10. PALACE MALICE, Mike Smith, Todd Pletcher 11. ...

Source: http://news.yahoo.com/kraft-foods-profit-declines-201553662.html

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Thursday, May 2, 2013

The Best Things to Buy in May

Spring is a great time to stock up on some new furnishings and other household items, especially in May. Here are the best things to buy this month.

Every month, we look back at the best times to buy anything during the year, and pull out items each month to remind you what's coming. Obviously, none of this is to say you should go on a shopping spree?but if you've been holding off for a lower price on something, these are the things that get the sale treatment in May.

All Spring

  • Televisions and Other Electronics: The Japanese fiscal year ends in March, which means Japanese-made goods?like the electronics we all love so much?are going to be on sale as they try to get rid of old stock. If you didn't grab a TV during the pre-Super Bowl sales, now's the time to grab one. Author Mark Di Vincenzo notes that these sales are probably even better than the February ones anyway, as long as you're comfortable buying last year's model.
  • Houses: According to Bankrate, spring is a great time to buy a house. Prices aren't quite as low as they can be in the winter, but you'll have a much larger selection to choose from, so you can take the time to find your perfect dream home. The spring weather makes the yards look great, and everyone comes out of the woodwork looking for a new home, which makes competition fierce. A lot of families start buying and selling at this time so their kids have time to make the transition during summer vacation, too.
  • Cookware & Kitchen Accessories: As graduation season draws closer, you'll see a lot of sales for common graduation gifts. Kitchen tools and cookware are at the top of the list, says Bankrate, so even if you aren't heading off to college next year, take advantage of the graduation-centric sales to stock up on any must-have kitchen tools now.
  • Digital Cameras: CES has come and gone, and while last year's digital cameras start going on sale in February, you're probably going to find the best deals during the second quarter of the year, according to Digital Photography School and Digital Camera HQ. Not sure what camera you want? Check out our Hive Five for DSLR and mirrorless 4/3 cameras.
  • Thrift Items: It's spring cleaning time, which means you can not only sell all your old junk, but buy other people's junk too! If you're a thrift store shopper, now's a good time to get even better bargains than usual, since places like the Salvation Army will be getting lots of new inventory.
  • Vacuum Cleaners: Speaking of spring cleaning, if your vacuum just doesn't have the sucking power that it used to, it's the perfect time to buy a new one. New vacuums usually don't come out until June, so Bankrate says you should grab the old models now as they're clearing them out (though if you can wait, Dealnews says Black Friday will see the lowest prices).

May

  • Office Furniture: Both Furniture Brains and DealNews note that office furniture tends to start dropping after Tax Day, and gets lower and lower once you get into June. If you've been looking to ergonomically optimize your workspace, now's the time?and you might start with one of the five most popular office chairs.
  • Mattresses: Even though mattresses usually come out all year round, May often sees some pretty great price drops, according to DealNews. And, as long as you do your pre-shopping research, there's no reason you can't still get a great one.
  • Refrigerators: Most big appliances go on sale later in the year, but refrigerators are the big exception. New models are on their way, says Money Crashers, which means last year's models are on sale. So, there's no better time to get a good discount on a barely outdated fridge for your newly rebooted kitchen.

We'll be posting updates for you guys every month, so you're aware of the deals going on all year round. If you're curious to see what's coming up, you can always check out our full best time to buy guide to see the entire year at a glance. And, if you know of any deals we didn't mention, share them in the comments below.

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/hpJw2GqfcXk/the-best-things-to-buy-in-may-5907155

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Google files patent for smartwatch with Glass-like touchpads and functionality

Image

Starting to get bored with Google Glass already? Well, it seems like Mountain View's trying to patent some of that functionality for a smartwatch, in a substantially different way than it did before. According to an application submitted to the USPTO, such a device would include standard smartwatch functions like a wireless transceiver, display and processor, but could also be equipped with two touchpads located on each side of the bezel. Those could enable "pinch, stretch and scroll on a platform with limited space available for user input," and would also communicate "with the clock line or data line." That means they'd control all the smartwatch functions, of course, but Google may be leaving the door open for it to control other devices as well, judging by the cagey wording -- perhaps sidestepping the need to reach for or yell at your eyewear.

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Source: USPTO

Source: http://www.engadget.com/2013/05/02/google-patent-smartwatch-glass/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Wanted: Polar bear spotter on Norwegian islands

OSLO, Norway (AP) ? Do you enjoy the outdoors and have strong vocal cords? If so, Norway might have a summer job for you: three weeks in the Arctic wilderness spotting polar bears.

The governor's office on the remote northern islands of Svalbard is seeking a polar bear spotter to warn researchers doing projects in the region.

The job starts July 8 and also requires previous experience with the outdoors, good polar bear spotting skills and a competence with firearms. But Helge Solli from the governor's office says the successful candidate likely won't have to use a gun "just as long as they have a loud voice" to scare off any bears.

There are an estimated 3,000 polar bears in the Svalbard archipelago, which has a human population of about 2,400.

Source: http://news.yahoo.com/wanted-polar-bear-spotter-norwegian-islands-141318515.html

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CA-NEWS Summary

Three men charged with undermining Boston bombing probe

BOSTON (Reuters) - U.S. authorities on Wednesday charged three men with interfering with the investigation of the Boston Marathon bombing, saying they hid fireworks and a backpack belonging to one of the suspected bombers as a manhunt was under way. The three, two students from Kazakhstan and a U.S. citizen, were described as college friends of surviving bombing suspect Dzhokhar Tsarnaev, 19. They were not charged with direct involvement in the April 15 marathon bombings, which killed three people and injured 264.

Italy's Letta wins French backing for focus on growth

ROME (Reuters) - Italy's new prime minister Enrico Letta won French backing on Wednesday for calls to spur economic growth alongside budget rigor, but problems lay closer to home with coalition partners demanding tax cuts that would blow a hole in the budget. Letta, who took his message to Berlin on Tuesday, met French President Francois Hollande and said he was "100 percent satisfied" with the meeting and Hollande's response to his calls for Europe to start focusing on growth as well as consolidation.

EU considers trade action after Bangladesh factory collapse

DHAKA (Reuters) - The European Union is considering trade action against Bangladesh, which has preferential access to EU markets for its garments, to pressure Dhaka to improve safety standards after a building collapse killed more than 400 factory workers. Duty-free access offered by Western countries and low wages have helped turn Bangladesh's garment exports into a $19 billion a year industry, with 60 percent of clothes going to Europe.

From Toronto to Dagestan; Canadian jihadi draws parallels with Tsarnaev

UTAMYSH, Dagestan, Russia (Reuters) - A mess of rubble, ash and charred vehicles is all that's left at the desolate farmhouse where a Canadian Muslim convert died fighting his last battle alongside Islamist insurgents in the Russian region of Dagestan. At the time, few people beyond local villagers noticed William Plotnikov's death in a region where skirmishes occur daily. But almost a year on, Plotnikov has emerged into the limelight following the Boston Marathon bombings.

Most Americans do not want U.S. involved in Syria: Reuters/Ipsos poll

WASHINGTON (Reuters) - Most Americans do not want to intervene in Syria's civil war, although the percentage in favor more than doubles if President Bashar al-Assad's forces use chemical weapons against their people, according to a Reuters/Ipsos poll released on Wednesday. Only 10 percent of those surveyed in the online poll said the United States should intervene in the fighting. Sixty-one percent opposed getting involved.

Turkey investigates use of chemical weapons in Syria

REYHANLI, Turkey (Reuters) - Turkey is testing blood samples taken from Syrian casualties brought over the border from fighting in recent days to determine whether they were victims of a chemical weapons attack, local government and health officials said on Wednesday. The samples were sent to Turkey's forensic medicine institute after several Syrians with breathing difficulties were brought to a Turkish hospital on Monday in the town of Reyhanli in Hatay province along the Syrian border.

Bolivia expels U.S. aid agency after Kerry 'backyard' comment

LA PAZ (Reuters) - Bolivian President Evo Morales expelled a U.S. development agency from his country on Wednesday, marking the latest confrontation between Washington and a bloc of left-wing governments in Latin America. Morales said he was kicking out the U.S. Agency for International Development (USAID) as a "protest" after U.S. Secretary of State John Kerry recently referred to Latin America as Washington's "backyard." The term evokes strong emotions in the region, which experienced several U.S.-backed coups during the Cold War.

At least 22 killed in Iraq attacks

RAMADI, Iraq (Reuters) - At least 22 people were killed in attacks across Iraq on Wednesday, police and medics said, after weeks of intensifying violence that threatens all-out sectarian conflict. Iraq has become increasingly volatile as the civil war in neighboring Syria strains fragile relations between Sunni and Shi'ite Muslims. Tensions are at their highest since U.S. troops pulled out of the country more than a year ago.

Japan PM's "stealth" constitution plan raises civil rights fears

TOKYO (Reuters) - Shinzo Abe makes no secret of wanting to revise Japan's constitution, which was drafted by the United States after World War Two, to formalize the country's right to have a military - but critics say his plans go deeper and could return Japan to its socially conservative, authoritarian past. Abe, 58, returned to office in December for a second term as prime minister and is enjoying sky-high support on the back of his "Abenomics" recipe for reviving the economy through hyper-easy monetary policy, big spending and structural reform.

Venezuelans hold rival May Day marches as vote dispute drags on

CARACAS (Reuters) - Opposition and government supporters flooded Venezuelan streets in rival May Day marches on Wednesday as a continuing dispute over the results of last month's presidential vote kept political tensions high in the OPEC nation. On Tuesday, opposition deputies were beaten in a fracas in Congress resulting from their refusal to recognize the presidency of Nicolas Maduro, who narrowly won the April 14 election triggered by the death of socialist leader Hugo Chavez.

Source: http://news.yahoo.com/ca-news-summary-005657182.html

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Wednesday, May 1, 2013

Film Threat - Full Lineup Announced For 2013 Seattle International ...

The 39th annual Seattle International Film Festival, running May 16-June 9, 2013, has announced its full programming lineup. From the official press release:

The Seattle International Film Festival, the largest and most-highly attended festival in the United States, announced today the complete schedule of films and events that will make up the 39th Seattle International Film Festival.

This year SIFF will screen 447 films: 272 features (plus 4 secret films), and 175 shorts representing 85 countries, including 49 World (18 Features, 31 Shorts), 48 North American (38 Features, 10 Shorts), and 17 US Premieres (6 Features, 11 Shorts). The festival will open with the previously announced screening of Joss Whedon?s Much Ado About Nothing, and close with the American premiere of Sofia Coppola?s The Bling Ring. The 2013 Seattle International Film Festival is produced by SIFF, the non-profit arts organization that reaches more than 250,000 annually through SIFF Cinema, SIFF FutureWave Education and the annual flagship Festival.

?My first knowledge of film festivals came from seeing astonishing and extraordinary films from the likes of Ridley Scott, Peter Greenaway, Lars von Trier and Bernardo Bertolucci. Today, those formative experiences drive my passion for finding the next wave of films from masters and undiscovered talent,? said SIFF Artistic and Co-Director Carl Spence. ?From the launch of our inaugural African Pictures program, to our Closing Night Gala, the American debut of Sofia Coppola?s The Bling Ring, to Disney? Pixar?s Monsters University, to Peter Greenaway?s Goltzius and the Pelican Company, the 39th edition of the Festival will unleash an incredibly rich and diverse array of fantastic programming.?

This year?s films feature a star-studded lineup including, Steve Carell, Toni Collette, Allison Janney, Sam Rockwell, and Maya Rudolph in Nat Faxon and Jim Rash?s The Way, Way Back; Helen Hunt, Samantha Morton, Aaron Paul, Bradley Whitford and Rashida Jones in Steven Bernstein?s Decoding Annie Parker; Paul Rudd and Emile Hirsch in David Gordon Green?s Prince Avalanche; Rooney Mara, Casey Affleck and Ben Foster in David Lowery?s Ain?t Them Bodies Saints; Greta Gerwig and Mickey Summer in Noah Baumbach?s Frances Ha; Shailene Woodley, Brie Larson, and Jennifer Jason Leigh in James Ponsoldt?s The Spectacular Now; Vera Farmiga and Andy Garcia in the World Premiere of Adam Rodgers? Middleton; and Olivia Wilde, Jake Johnson, Anna Kendrick, Ron Livingston, and Ti West in Joe Swanberg?s Drinking Buddies.

?This is my first year at SIFF as Managing Director, however I have been involved with the organization for many, many years ? from participating as a sponsor, to covering as a reporter, to serving as a volunteer,? said SIFF Managing Director Mary Bacarella. ?I?m overjoyed to kick off my tenure as Managing Director with such an exciting Festival lineup; it?s going to be a spectacular 25 days of celebrating the world of film.?


GALAS:

Opening Night Gala
Much Ado About Nothing (director: Joss Whedon)
Shakespeare?s classic comedy is given a contemporary spin in Whedon?s Much Ado. Shot in just 12 days (and using the original text), the story of sparring lovers Beatrice and Benedick offers a dark, sexy, and occasionally absurd view of the intricate game that is love. The film was shot entirely in Whedon and Cole?s own home, and made with a group of close friends (and recurring ?Whedonverse? players) who share the filmmakers? love of Shakespeare. Confirmed to attend Opening Night on May 16 are director Whedon and the stars of the film: Alexis Denisof, Amy Acker, Nathan Fillion, and Clark Gregg.

Closing Night Gala
The Bling Ring (director: Sofia Coppola) North American Premiere
Coppola?s latest is a story ripped from the tabloid headlines and gossip news programs, a story as strange as it is true. Five Tinseltown teenagers (two played by Emma Watson and Taissa Farmiga) wish to live like the rich and famous, but they?ll settle for robbing them instead. The gang, referring to themselves as ?The Bling Ring,? track the internet goings-on of SoCal?s A-list celebs with ease, waiting for just the right moment to break into their vast mansions and run off with their high-class goods. But when rebelliousness turns to recklessness, the group?s crimes catch up with them.

Centerpiece Gala
Twenty Feet from Stardom (director: Morgan Neville)
When you?re singing along with the chorus of your favorite song, do you really know who you?re singing along with? Veteran filmmaker Morgan Neville does, and his new film tracks the astounding careers, contributions, and sacrifices of pop music?s most-recognizable, yet least-known artists: the backup singers. Twenty Feet from Stardom follows several diverse and gifted backup singers living in the shadows of superstardom. Although these singers are usually relegated to the margins, and few, if any, become household names, their work has defined countless songs that remain in our hearts and collective consciousness. Director Morgan Neville and singers Tata Vega and Merry Clayton are scheduled to appear and perform at the screening.


Films with Parties:
Drinking Buddies (director: Joe Swanberg, USA, Magnolia Pictures)
Fanie Fourie?s Lobola (director: Henk Pretorius, South Africa)
G.B.F. (director Darren Stein, USA)
Populaire (director: R?gis Roinsard, France, The Weinstein Company)
The Way, Way Back (directors: Nat Faxon, Jim Rash, USA, Fox Searchlight)
Special Guests:
SIFF highlights two special guests this year: legendary actor Kyle MacLachlan and director Peter Greenaway.

Washington native Kyle MacLachlan has brought his patented brand of effortless charm and fierce tenacity the big and small screens. This program will include the presentation of the Seattle International Film Festival Award for Outstanding Achievement in Acting, an onstage interview with film clips from his career, including an audience Q&A, followed by a screening of David Lynch?s pilot for the cult-hit television show Twin Peaks.

Peter Greenaway, one of film?s leading provocateurs, provides a premise and a challenge in his upcoming forum: is the contemporary cinema?s dependence on text leading to the death of cinema? Illustrated with numerous clips and striking visual imagery, Peter Greenaway?s lecture promises to be enlightening and exciting adventure. The talk will follow a screening of Goltzius and the Pelican Company.


Special Presentations:
This year?s Special Presentations include:
Decoding Annie Parker (director: Steven Bernstein) ? Starring Helen Hunt and Samantha Morton, this is the amazing true story of UW geneticist Mary-Claire King and her world-changing discovery of the BRCA1 breast cancer gene. Special benefit screenings will support the fight against breast cancer.
Inequality for All (director Jacob Kornbluth) ? the Sundance award-winning documentary exploring the causes and consequences of the widening income gap in America.
Somm (director: Jason Wise) ? the riveting story of four sommeliers attempting to pass the prestigious Master Sommelier exam. This film will be paired with special wine tasting receptions following the screenings. Director Jason Wise expected to attend along with renowned Sommeliers.
Feature FILM Premieres:
World (18):
9 Full Moons (d: Tomer Almagor, USA)
Alive and Well (d: Josh Taft, USA)
Clutter (d: Diane Crespo, USA)
Evergreen: The Road to Legalization in Washington (d: Riley Morton, USA)
Fateful Findings (d: Neil Breen, USA)
Finding Hillywood (d: Leah Warshawski, USA)
Her Aim Is True (d: Karen Whitehead, USA)
Last I Heard (d: David Rodriguez, USA)
The Little Tin Man (d: Matthew Perkins, USA)
Middleton (d: Adam Rodgers, USA, Anchor Bay Films)
Mutual Friends (d: Matthew Watts, USA)
The Otherside (d: Daniel Torok, USA)
Scrapper (d: Brady Hall, USA)
Spud 2: The Madness Continues (d: Donovan Marsh, South Africa)
Teddy Bears (d: Thomas Beatty, USA)
Test (d: Chris Mason Johnson, USA)
Town Hall (d: Jamila Wignot, USA)
Worm (d: Andrew Bowser, USA)

North American (38):
36 (d: Nawapol Thamrongrattanarit, Thailand)
The African Cypher (d: Bryan Little, South Africa)
Ali (d: Paco R. Ba?os, Spain)
Belleville Baby (d: Mia Engberg, Sweden)
Between Valleys (d: Philippe Barcinsk, Brazil)
Bitch Hug (d: Andreas ?hman, Sweden)
The Bling Ring (d: Sofia Coppola, USA, A24)
Breach in the Silence (d: Andr?s Rodr?guez, Venezuela)
Bypass (d: Patxo Telleria, Spain)
Capturing Dad (d: Ryota Nakano, Japan)
Celestial Wives of Meadow Mari (d: Aleksey Fedorchenko, Russia)
Closed Curtain (d: Jafar Panahi, Iran)
Comrade President (d: Mosco Kamwendo, Zimbabwe)
Dead Meat Walking ? A Zombie Walk Documentary (d: Omar J. Pineda, USA)
Drug War (d: Johnnie To, Hong Kong, Well Go USA)
?den (d: Bruno Safadi, Brazil)
Every Blessed Day (d: Paolo Virzi, Italy)
Fatal (d: Lee Don-ku, South Korea)
Flight of the Storks (d: Jan Kounen, France)
Garibaldi?s Lovers (d: Silvio Soldini, Italy, Film Movement)
The Girl With Nine Wigs (d: Marc Rothemund, Germany)
The Great Passage (d: Y?ya Ishii, Japan)
House With a Turret (d: Eva Neymann, Ukraine)
I Kori (The Daughter) (d: Thanos Anastopoulos, Greece)
The Kampala Story (d: Donald Mugisha, Uganda)
Last Flight to Abuja (d: Obi Emelonye, Nigeria)
Love Is in the Air (d: Alexandre Castagnetti, France)
Low Profile (d: C?cilia Rouaud, France)
Ludwig II (d: Peter Sehr, Germany)
My Dog Killer (d: Mira Fornay, Slovakia)
Nishan (Medal of Honor) (d: Yidnekachew Shumete Desalegn, Ethiopia)
The Plague (d: Neus Ball?s, Spain)
Redemption Street (d: Miroslav Terzi, Serbia)
Ripples of Desire (d: Zero Chou, Taiwan)
Short Stories (d: Mikhail Segal, Russia)
Television (d: Mostofa Sarwar Farooki, Bangladesh)
Tito on Ice (d: Max Andersson, Germany)
Yesterday Never Ends (d: Isabel Coixet, Spain)

US (6):
2+2 (d: Diego Kaplan, Argentina, Strand Releasing)
Aayna Ka Bayna (d: Samit Kakkad, India)
Alice Walker: Beauty in Truth (d: Prathiba Parmar, USA)
Breathing Earth (d: Thomas Riedelsheimer, Germany)
Horses of God (d: Nabil Ayouch, Morocco)
Invader (d: Daniel Calparsoro, Spain)


African Pictures Program:
This year SIFF will launch its African Pictures Program, a program made possible by a grant from the Academy of Motion Picture Arts and Sciences. The African Pictures Program aims to celebrate the diverse and burgeoning hotbed of filmmaking activity emerging across the continent of Africa. This grant gives SIFF an unparalleled opportunity as a major international film festival to showcase a substantive program of indigenous films from Africa along with films by African filmmakers working outside the continent. Please click here for the complete African Pictures Program press release. See below for the full lineup:

The African Cypher (d:Bryan Little, South Africa, North American Premiere)
After the Battle (d: Yousry Nasrallah, France)
Coming Forth by Day (Hala Lotfy, Egypt)
Comrade President (d: Mosco Kamwendo, Zimbabwe, North American Premiere)
Die Welt (d: Alex Pitstra, Netherlands)
Fanie Fourie?s Lobola (d: Henk Pretorius, South Africa)
Finding Hillywood (Leah Warshawski, USA, World Premiere)
The Forgotten Kingdom (d. Andrew Mudge, USA)
A Hijacking (d. Tobias Lindholm, Denmark)
Horses of God (d: Nabil Ayouch Morocco, US Premiere)
The Kampala Story (d:Donald Mugisha, Uganda, North American Premiere)
Last Flight to Abuja (d: Obi Emelonye, Nigeria, North American Premiere)
Mother of George (d: Andrew Dosunmu, USA, Oscilloscope Laboratories)
Nishan (Medal of Honor) (d: Yidnekachew Shumete Desalegn, Ethiopia)
The Pardon (d: Joel Karekezi, Rwanda, North American Premiere)
The Repentant (d: Merzak Allouache, Algeria)
Sand Fishers (d: Samout? Andrey Diarra, Mali)
Spud 2: The Madness Continues (d: Donovan Marsh, South Africa, World Premiere)


COMPETITIONS:
SIFF competitions are intended to reflect the diversity and excellence of global filmmaking with awards and/or cash prizes given to the winners as determined by independent juries as well as by audience voting.

New Directors Competition: Festival programmers select 12 films remarkable for their original concept, striking style and overall excellence. To be eligible films must be a director?s first or second feature and without U.S. distribution at the time of their selection. Winners receive a $2,500 cash prize.

Breach in the Silence (d: Andres Rodriguez, Luis Rodriguez, Venezuela, North American Premiere)
The Cleaner (d: Adrian Saba Peru 2012)
Coming Forth by Day (d: Hala Lotfy, Egypt/United Arab Emirates 2012)
Die Welt (d: Alex Pitstra, Netherlands/Tunisia/Qatar, 2012)
Fatal (d: Lee Don-ku, South Korea 2012, North American Premiere)
Fuck Up (d: ?ystein Karlsen, Norway 2012)
Harmony Lessons (d: Emir Baigazin, Kazakhstan/Germany/France, 2013)
House With a Turret (d: Eva Neymann, Ukraine 2012, US Premiere)
Love is in the Air (d: Alexandre Castagnetti, France 2013, North American Premiere)
The Plague (d: Neus Ball?s, Spain 2013, North American Premiere)
Sadourni?s Butterflies (d: Dario Nardi, Argentina 2012)
Short Stories (d: Mikhail Segal, Russia 2012, North American Premiere)

New American Cinema Competition: Festival programmers select 12 films without U.S. distribution that are sure to delight audiences looking to explore the exciting vanguard of New American Cinema and compete for the FIPRESCI Award for Best New American Film. Jury is comprised of 3 members from the International Federation of Film Critics. The winning film will receive a copy of Adobe Creative Suite 6: Production Premium edition.

9 Full Moons (d: Tomer Almagor, USA 2013, World Premiere)
Clutter (d: Diane Crespo, USA 2013, World Premiere)
C.O.G. (d: Kyle Patrick Alvarez, USA 2013)
The Forgotten Kingdom (d: Andrew Mudge, USA 2013)
Last I Heard(d: David Rodriguez, USA 2013, World Premiere)
The Little Tin Man (d: Matthew Perkins, USA 2013, World Premiere)
The Moment (d: Jane Weinstock, USA 2013)
Mutual Friends (d: Matthew Watts, USA 2013, World Premiere)
A Song Still Inside (d: Gregory Collins, USA 2013)
Teddy Bears (d: Thomas Beatty, Rebecca Fishman, USA 2013, World Premiere)
Test (d: Chris Mason Johnson, USA 2013, World Premiere)
Worm (d: Andrew Bowser, USA 2013, World Premiere)

Documentary Competition: Unscripted and uncut, the world is a resource of unexpected, informative, and altogether exciting storytelling. Documentary filmmakers have, for years, brought these untold stories to life and introduced us to a vast number of fascinating topics we may have never known existed?let alone known were so fascinating. Winners receive a $2,500 cash prize.

The African Cypher (d: Bryan Little, South Africa 2012, North American Premiere)
Alice Walker: Beauty in Truth (d: Prathiba Parmar, USA 2013, US Premiere)
Breathing Earth (d: Thomas Riedelsheimer, Germany/Scotland 2012, US Premiere)
The Crash Reel (d: Lucy Walker, USA 2013)
Her Aim Is True (d: Karen Whitehead, USA 2013, World Premiere)
Mussels in Love (d: W.J.A. Kluijfhout, Netherlands 2012)
Our Nixon (d: Penny Lane, USA 2013)
The Punk Singer (d: Sini Anderson, USA 2013)
Sand Fishers (d: Samout? Andrey Diarra, Mali/France 2012)
Town Hall (d: Jamila Wignot, Sierra Pettengill, USA 2013, World Premiere)
The Trials of Muhammad Ali (d: Bill Siegel, USA 2013)
A World Not Ours (d: Mahdi Fleifel, Lebanon/United Kingdom/Denmark, 2012)

SIFF Shorts Competition: All short films shown at the Festival are eligible for both the Golden Space Needle Audience Award and Jury Award. Shorts Competition. Jurors will choose winners in the Live Action, Animation, and Documentary categories. Each jury winner will receive $1,000 and winners in any of the three categories may also qualify?to enter their respective films in the Short Film category of the Academy Awards?.

Golden Space Needle Awards / Artist Piper O?Neill
For the past 28 years, SIFF has celebrated its most popular films and filmmakers with the Golden Space Needle Audience Award. Created to recognize audience?s favorite films, awards are given to the Festival?s Best Feature Film, Documentary, Actor, Actress, and Short Film. Piper O?Neill is a Seattle-based artist who has been commissioned to create this year?s Golden Space Needle Award. The award?s design was inspired by the DeJur Electra 8mm camera lens introduced in the 1960s, especially by the beautiful and iconographic silhouette of the lens, symbolic of Seattle?s love of film. With an impressive body of work, Piper O?Neill will mount her second solo exhibition at Winston Wachter Fine Art in January 2014.


Face the Music:
Seattle is one the greatest music cities in the world, so it?s only fitting that SIFF feature a wide array of music-themed films and events. Special live music events include A Muscle Shoals Tribute with Patterson and David Hood, and The Maldives perform The Wind.

Face the Music also showcases films that intersect the world of music on all fronts: from biopics and concert films to musicals and live events. Film highlights include Twenty Feet from Stardom, a fascinating documentary about backup singers and Kathleen Hanna documentary The Punk Singer.


Northwest Connections:
Seattleites see more films per capita than the residents of any other American city, and a growing number of these selections have their roots in the fertile Pacific Northwest film community. Each year, SIFF honors the many ways in which the Puget Sound region contributes to the world of cinema, whether it acts as an evocative location for outside filmmakers or as inspiration for local filmmakers ready to strut their stuff. This year?s Northwest Connections films include Improvement Club (director: Dayna Hanson), Her Aim is True (director: Karen Whitehead), and Middleton (director: Adam Rodgers). Full list below:

Alive and Well (d: Josh Taft, USA, World Premiere)
Barzan (d: Alex Stonehill, USA)
Big Joy: The Adventures of James Broughton (d: Eric Slade, USA)
Dead Meat Walking ? A Zombie Walk Documentary (d: Omar J. Pineda, USA)
Evergreen: The Road to Legalization in Washington (d: Riley Morton, USA, World Premiere)
Finding Hillywood (Leah Warshawski, USA, World Premiere)
Her Aim Is True (d: Karen Whitehead, USA, World Premiere)
Improvement Club (d: Dayna Hanson, USA)
Middleton (d: Adam Rodgers, USA, Anchor Bay Films, World Premiere)
The Otherside (d: Daniel Torok, USA, World Premiere)
The Punk Singer (d: Sini Anderson, USA)
Shadowed (d: Joey Johnson, USA)
Scrapper (d: Brady Hall, USA, World Premiere)
Touchy Feely (d. Lynn Shelton, USA)
Unhung Hero (d: Brian Spitz, USA


FESTS:

DocsFest,
Music, dance, art, sports, history, politics, the natural world. SIFF is proud to present nearly 70 documentaries this year throughout the festival, from the love lives of mussels (Mussels in Love) to the life and times of Muhammad Ali (The Trials of Muhammad Ali), from the home movies of President Richard Nixon (Our Nixon) to We Steal Secrets: the Story of WikiLeaks. New this year, a concentration of documentaries, DocsFest, takes place during the third weekend of the festival (May 31 ? June 2).

ShortsFest
SIFF?s annual celebration of the short film has become one of the hot tickets at the Festival. ShortsFest takes place during Memorial Day Weekend, and is a mini-fest packed with talented up-and-coming filmmakers from around the world. Take advantage of an exciting opportunity to experience the best short films from the past year.


MOODS:

?What sort of film do I feel like seeing tonight?? With our handy Moods groupings, we?ve made it easy to find the type of cinematic experience you?re in the mood for. Instead of using traditional categories, which require a bit of work to figure out, we?ve aimed to connect films with you, the audience, by organizing them into 10 areas that match your mood.

Love: Romance and love in all its forms, pleasures, and idiosyncrasies.

Make Me Laugh: Films that make you chuckle and tickle your funny bone.

Open My Eyes: Revealing films and documentaries revolving around history, politics, and contemporary events from around the world.

Provoke Me: Mesmerizing dramas and documentaries that explore thought-provoking questions, realities, and topics.

Thrill Me: Suspense, thrills, and action. Films with a faster pace that might also surprise you when you least expect it!

Show Me the World: Prepare to be taken to another place? from exotic, far-off lands to vibrant experiences outside of everyday life.

Sci-Fi and Fact: Science, technology, environment,?the future??and beyond!

To the Extreme: Explore the outer limits with films that go beyond the edge.

Creative Streak: The exploration of artistic endeavors from all disciplines: literature, film, art, dance, and performance.

Face the Music: Films that intersect the world of music on all fronts: from biopics and concert films, to musicals and live events.


Fly Filmmaking Challenge 2013:
With only three days to shoot, five days to edit, and three days of post-production, this year?s Fly Filmmaking Challenge is a true partnership of our creative communities. The undeniable talents of the 2012 fellows from Artist Trust serve as the inspiration behind each script, with Seattle?s most iconic neighborhood locations supplying the backdrop of an incredibly entertaining program. These creative hurdles, couples with a documentary narrative from the most promising local educational filmmaking programs, form the whole picture that highlights Washington?s filmmaking community.

Fly Filmmakers: Ben Andrews, Amy Enser, Lulu Gargiulo, Curtis Taylor

Artist Trust Fellows: Samantha Boshnack, Samuel Green, Jovino Santos Neto, Derek Sheffield

Educational Filmmaking Programs: Art Institute of Seattle, Seattle Central Community College, Seattle University, Shoreline Community College


SIFF EDUCATION:
SIFF Education offers three programs during Festival: FutureWave & Films4Families, Festival Forums, and SuperFly.

FUTUREWAVE AND FILM4FAMILIES FESTIVAL PROGRAMMING:
SIFF has two programs curated to make the Festival more accessible for younger audiences: FutureWave features are a great place for our cinema-savvy teen audience to find their love of world cinema and Films4Families is the perfect way for younger children (and the young at heart) to have a fabulous experience at SIFF. Both programs also have Youth Juries comprised of youth from their age bracket to watch all the films and present the Youth Jury Award in their respective categories.

FESTIVAL FORUMS & PANELS:
Where audiences and filmmakers come together to learn about and experience making movies. See below for a complete list:

Panel: Transition from Stage to Screen
New Queen Cinema with B. Ruby Rich
Inside Stunts: Meet the Men and Women that Pack the Punch into our Movies
Get Animated: Animation Workshop for Kids
Short Filmmakers Happy Hour & Panel: Making the Most of Any Festival
Rule the World of Independent Filmmaking From Indie Distribution to Smart Phone Productions
Sheroes in Media: From Guerrilla Girls to Women in Film
The Alchemy of Film Scoring
Digital Storytelling in the Classroom: A Professional Development Workshop for Teachers
Behind the Curtain of Documentary Filmmaking
SIFF Crash Cinema Part I: PRE-PRODUCTION
SIFF Crash Cinema Part I: PRODUCTION Shooting/Editing/ Screening
Resources for the Modern Filmmaker
First Draft
Getting the Most out of the Media
Acting for the Camera with Story Town Studios
What?s Your Style: High School Filmmakers Scene Workshop
State of the Industry with Amy Lillard

SUPERFLY 2013
For its eighth year, the SuperFly Filmmaking Experience, created by Longhouse Media and presented by SIFF, brings 50 youth from across the country to Seattle to participate in an immersion into filmmaking and tribal culture. The young filmmakers will produce five short documentary films in 36 hours at the Suquamish Tribal Community.

The films will be completed just hours before their World Premiere at the SuperFly and Native Shorts Showcase on June 1 (4:00pm, Harvard Exit).


SIFF ? Seattle
Venues: SIFF Cinema Uptown, SIFF Film Center, McCaw Hall, Pacific Place Cinemas, Cinerama, Egyptian Theatre, Harvard Exit, SIFF Lounge at the Tin Lizzie, The Triple Door

SIFF ? Renton
SIFF is proud to be returning to Renton for a third year where it will host six days of film screenings at the Renton IKEA Performing Arts Center from May 23 to 29. SIFF wishes to thank the City of Renton, the Renton Chamber of Commerce/Renton Visitors Connection, Renton School District, Renton Technical College and Valley Medical Center. SIFF-Renton will open with Lynn Shelton?s Touchy Feely.

SIFF ? Kirkland
For the fifth year, SIFF returns to Kirkland (May 30 to June 9) where it will open with Marcus Markou?s Papadopoulos & Sons. Screenings will take place at the Kirkland Performance Center. SIFF wishes to thank the City of Kirkland for its hospitality.


Festival Box Office opens in person and online May 2. On that date, and after, browse the full public program at www.siff.net/festival-2013.
SIFF 2013 by the Numbers:
447 Films
85 Countries
197 Narrative Feature Films (+ 4 Secret Films)
67 Documentary Features
8 Archival Films
175 Short Films
49 World Premieres (18 Features, 31 Shorts)
48 NA Premieres (38 Features, 10 Shorts)
17 US Premieres (6 Features, 11 Shorts)

Source: http://www.filmthreat.com/festivals/65503/

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